9 Synthroid Side Effects That Might Mean Your Dosage Is Way Off

Approximately 80% of the daily dose of T4 is deiodinated to yield equal amounts of T3 and reverse T3 (rT3). Thyroid hormones are also metabolized via conjugation with glucuronides and sulfates and excreted directly into the bile and gut where they undergo enterohepatic recirculation. Because of the increased prevalence of cardiovascular disease among the elderly, initiate SYNTHROID at less than the full replacement dose see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS. Atrial fibrillation is the most common of the arrhythmias observed with levothyroxine overtreatment in the elderly. Rapid restoration of normal serum T4 concentrations is essential for preventing the adverse effects of congenital hypothyroidism on cognitive development as well as on overall physical growth and maturation.

Absorption of orally administered T4 from the gastrointestinal tract ranges from 40% to 80%. The majority of the SYNTHROID dose is absorbed from the jejunum and upper ileum. The relative bioavailability of SYNTHROID tablets, compared to an equal nominal dose of oral levothyroxine sodium solution, is approximately 93%. T4 absorption is increased by fasting, and decreased in malabsorption syndromes and by certain foods such as soybeans. In addition, many drugs and foods affect T4 absorption see DRUG INTERACTIONS. Published studies report that levothyroxine is present in human milk following the administration of oral levothyroxine.

Additionally, prescription of an adjuvant medication may decrease tremors or shakiness. Most individuals won’t swell to gigantic proportions, but it may be obvious that some swelling has occurred. For certain users, swelling may be most noticeable when first beginning treatment and thereafter, it may completely subside. That said, the swelling may be significant enough to cause joint and/or muscle pain – especially if it worsens over time. If you’re experiencing insomnia, you may derive benefit from sedative/hypnotic supplements and/or Z-drugs (pharmaceutical sleeping pills).

Taking control of your health

Since synthroid is a synthetically engineered form of T4, it is necessary to consider that for some users, increased bodily temperature may also be a result of inability to tolerate a non-bioidentical (synthetic) hormone. It should be noted that fevers are often accompanied by chills and possibly sweats. Should you experience an incessant fever that fails to subside after weeks of synthroid treatment – it may be a sign that your body is unable to tolerate it.

Synthroid (Levothyroxine) Side Effects & Adverse Reactions

No adverse effects on the breastfed infant have been reported and there is no information on the effects of levothyroxine on milk production. Adequate levothyroxine treatment during lactation may normalize milk production in hypothyroid lactating mothers with low milk supply. Following these exact dosing instructions may prevent certain side effects from occurring and maximize likelihood of therapeutic efficacy. Most synthroid users will fall in between the extremes of “intolerability” and “optimal tolerability.” You may find that synthroid treats your hypothyroidism, but also causes dry skin, moodiness, and modest weight changes.

Dried Blood Spot Testing for Hypothyroidism

• While not everyone will experience and/or notice daytime sweating, others may notice that their bed sheets are drenched in sweat upon waking.
• While the reasons behind the disproportionate rate of Hashimoto’s in women (seven women for every one man) are complex, the heavy use of endocrine-disrupting chemicals may be a contributing factor.
• SYNTHROID is indicated in adult and pediatric patients, including neonates, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
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If you’re experiencing side effects from taking synthroid 30 minutes before breakfast, you may need to increase the gap between synthroid ingestion and food consumption to 60 minutes. Additionally, if you’ve been somewhat inconsistent in timing of administration – this could increase side effects. Instructions for dosing with synthroid should be reviewed prior to initial administration. Many people taking synthroid listen to their doctor’s dosing instructions, as well as those given by a pharmacist, but fail to actually implement them.

• Since the severity of hypothyroidism is subject to individual variation and synthroid dosages necessitate patient-specific optimization, “too much synthroid” for one user may be a normal dose for another.
• Getting drenched in sweat at the gym is the hallmark of a killer workout, but everywhere else?
• Synthroid therapy in nursing mothers is usually safe but should be supervised by a physician.
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However, you may also notice the onset of some new side effects that didn’t occur during the short-term. The emergence of new side effects should be carefully monitored, as they may progressively worsen with continued treatment. Always realize that co-ingested substances can either cause contraindications (interactions), as well as potentiate or mitigate various neurophysiological responses to synthroid. Be sure to review the dosages of the co-administered substances as well as times of administration with a medical doctor to minimize likelihood of interaction-based side effects. If you are experiencing tremors from synthroid, these should be discussed with your doctor. It is possible that your dosage may need adjusting and/or that a different medication may reduce the occurrence of tremors.

• If you never had joint problems prior to taking synthroid, and suddenly noticed muscle weakness, swelling, and pain – there’s a good chance that it’s the medication.
• The relative bioavailability of SYNTHROID tablets, compared to an equal nominal dose of oral levothyroxine sodium solution, is approximately 93%.
• Time of dosing as well as whether synthroid is taken without food – are important factors that affect therapeutic response rates and side effects.
• These side effects may go away during treatment as your body adjusts to the medicine.
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• Lead can be found in old paint, pipes, and some cosmetics, and chronic lead exposure has been linked to hypothyroidism.

Taking Too Much Synthroid: Interindivdiual Variation in Dosing

It may turn out that the side effects you thought were from synthroid, were actually from another co-administered substance. Achy muscles may interfere with your ability to exercise regularly, which in turn may further compromise your overall health – and especially the health of your muscles. Synthroid is a synthetic hormone that isn’t always well-tolerated by the body. Muscle aches may be one of many possible reactions generated by the body as a signal that the exogenous substance is difficult to tolerate.

As you work with your practitioner to pinpoint the optimal synthroid dosage and continue taking the medication, hot flashes may subside. If prior to taking synthroid you have a history of blood pressure abnormalities, your doctor should be well-informed of these and adjust dosing to mitigate risks of hypertension. In some cases, synthroid users may necessitate adjuvant treatment with a beta blocker to offset the side effect of hypertension.